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Cryo-EM Scientist
Competitive Salary, Excelent Beneftis
Michael Glaze-Santonen
Cryo-EM Scientist Position, Cambridge. Multiple Roles.

A world leading Biotechnology company situated in Cambridge, well known for an innovative approach to drug discovery and development, is seeking multiple Cryo-EM Scientists / Structural Cell Biologists, as part of ambitious plans to continually improve its services in the fields of Neurological Disorders and Oncology.

Role Overview;

Working in a state-of-the art CRYO-EM facility, the successful candidates will be performing pioneering work to deliver atomic resolutions structures which in turn support structure-based and fragment-based drug discovery. Where once X-Ray crystallography was used, the increased ability of Cryo-EM has led to significant improvements in the drug discovery and development process.
The facility includes 2 Glacios and 1 Krios transmission electron microscopes as well as a fully equipped Cryo-EM sample preparation Laboratory and sophisticated computing infrastructure. Further to this, you’ll also be working with custom data collection workflows which facilitate the rapid generation and interpretation of Cryo-EM structures for structure-based drug discovery and fragment-based drug discovery.

Candidates should be collaborative, communicative, driven and excited by the prospect of working with some of the most exciting and cutting-edge technology in the drug discovery and development world.

Experience / Knowledge Sought;

The successful candidate(s) will hold a PhD and experience in one or more of the areas listed below; please note this is a #39&wish list#39& and experience with all is not expected:

*Expression, purification and characterisation of proteins, ideally including membrane proteins or protein complexes
*Experience in performing single particle Cryo-EM on a range of targets
*Generation, optimisation and analysis of negative stain and Cryo-EM grids
*Experience in the processing of single particle Cryo-EM data and familiarity with related software packages


*Experience in using other biophysical methods in protein characterisation and protein-ligand interactions.

What’s on Offer;

The successful candidates will receive a competitive salary, generous annual leave allowance and excellent benefits. The positions are initially for a 2 year Fixed-Term period. There exists scope for extending this thereafter for interested candidates. From a career perspective the successful candidates will be able to add a genuine world leading biotechnology company to her / his CV and high job satisfaction derived from knowing that the work you’ll be doing will make a real difference.

If you feel that you have the required experience for the position we would love to hear from you so please email us a copy of your CV in the first instance.

Whilst we would like to respond to each application individually, we often receive over 200 applications per role and doing so is not feasible unfortunately. That said we are happy to be "pursued" if you feel strongly on the matter so be persistent and we will do our best to reply!

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