to £22k plus great benefits
Based in Wetherby, my client is a preclinical phase market leader in the next generation of Biotherapeutics to meet the growing demand for the next generation of drugs that will compete with monoclonal antibodies and other antibody mimetics, primarily in oncology. The expansion of their research activities at Wetherby has created an opportunity for a ersearch associate within their production team.
The role will be a member of the Production team responsible for the expression and purification of proteins for internal and customer facing projects. This mainly involves E. coli expression but the team will also need to use other expression modalities. The team handles all aspects of protein production from cell culturing through induction, growth monitoring, and cell harvesting to material processing, chromatography (preparative and analytical) and SDS-PAGE. The team are also expected to be able to use molecular biology techniques to re-clone constructs to produce alternative fusion proteins as required for specific projects.
Main Duties and Responsibilities;
+ Express and purify proteins for internal and custom projects
+ Characterisation of proteins
+ Produce high quality proteins and tool molecules for internal or custom projects, following WI.
+ Maintain equipment, maintain databases and shared lab stocks
+ Degree/HND in Molecular Biology, Biochemistry, Biotechnology or related discipline or equivalent experience.
+ Awareness of standard protein production techniques working with a range of protein expression platforms (e.g., bacterial and mammalian).
+ Knowledge of standard protein engineering techniques, including cloning, sub-cloning and reformatting of protein constructs.
+ Awareness of the ÄKTA purification platform, Unicorn software and using conventional chromatography resins.
+ Knowledge of a range of methodologies to characterise proteins (e.g., SDS-PAGE, Western blot).
Our client are located in a state-of-the-art building on a large site outside of Wetherby with ample free parking, there is an exciting and innovative environment within the Company with varied opportunities to develop your skill set. On offer is an attractive benefits package which includes competitive salaries, company pension with up to 6% matching contributions, death in service benefit, annual performance related share awards and the option to join the Share Incentive Plan.
If this role sounds of interest pleae contact Matt Slinger on 0161 923 8173.
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